LAG-3 Extracellular Domain (human, recombinant)-其他重组蛋白-ELISA_抗体_蛋白_核苷酸

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LAG-3 Extracellular Domain (human, recombinant)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：32083-50 µg	规格：50 µg	目录价：￥3528
货号：32083	规格：500 µg	目录价：￥22914

产品详情

产品名称:

LAG-3 Extracellular Domain (human, recombinant)

别名:

CD223|Lymphocyte Activation Gene 3 Protein

产品描述:

Lymphocyte activation gene 3 (LAG-3) protein is a CD4-like protein and member of the immunoglobulin superfamily (IgSF) that binds with high affinity to MHC class II molecules.{56111,56112} LAG3 is expressed in activated T cells and natural killer cells, and the protein functions as an inhibitory co-receptor that modulates T cell homeostasis, proliferation, expansion, activation, and function.{56113,56114,56112} LAG-3 is comprised of an N-terminal extracellular domain with four IgSF domains, a transmembrane domain, and a C-terminal cytoplasmic domain with a KIEELE motif required for modulation of T cell function.{56111,56113,56112} Elevated LAG3 expression in chronic lymphocytic leukemia (CLL) cells is associated with reduced treatment-free survival in patients with CLL.{56115} Co-administration of antibodies against both LAG-3 and PD-1 reduces the number and percentage of CLL cells in blood and spleen in a CLL-splenocyte adoptive transfer mouse model.{56116} SNPs in LAG3 are associated with susceptibility to multiple sclerosis.{56117} Cayman's LAG-3 Extracellular Domain (human, recombinant) protein consists of 433 amino acids, has a calculated molecular weight of 47 kDa, and a predicted N-terminus of Val29 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 50 to 60 kDa due to glycosylation.

保存温度:

-80

运输温度:

-80

产品形式:

Lyophilized from sterile PBS, pH 7.4

有效期:

365

纯度:

≥95% estimated by SDS-PAGE

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