货号:32082-1 mg | 规格:1 mg | 目录价:¥38358 |
货号:32082 | 规格:100 µg | 目录价:¥5904 |
产品详情
产品名称:
SIRPα Extracellular Domain (human, recombinant)
别名:
CD172 Antigen-like Family Member A|CD172A|MyD-1 Antigen|SHP Substrate 1|SHPS-1|Signal Regulatory Protein α
产品描述:
Signal regulatory protein α (SIRPα) is an inhibitory transmembrane receptor encoded by SIRPA in humans.{53810,53811} It is composed of three extracellular immunoglobulin-like (Ig-like) domains, a single transmembrane region, and a cytoplasmic domain that contains four tyrosine residues with immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are essential to SIRPα interaction with the Src homology region 2 (SH2) domain-containing phosphatases SHP-1 and SHP-2.{53811} SIRPα is expressed on monocytes, macrophages, granulocytes, subsets of dendritic cells in lymphoid tissues, some bone marrow progenitor cells, and neurons. Binding of CD47 (Item No. 32085), a receptor expressed on healthy cells but often overexpressed in cancer cells, to SIRPα induces phosphorylation of the SIRPα ITIMs, coupling to SHP-1 or SHP-2, and repression of immune cell activation and phagocytosis.{53810,53811} Knockout of Sirpa increases dopaminergic neuronal loss in the substantia nigra pars compacta and enhances striatal microglia activation in a mouse model of MPTP-induced Parkinson's disease.{53812} Sirpa-/- mice exhibit increased age-related podocyte injury and proteinuria compared with wild-type mice.{53813} SIRPA expression is decreased in patients with focal segmental glomerular sclerosis and in mouse models of renal injury induced by puromycin aminonucleoside (Item No. 15509), doxorubicin (Item No. 15007), or streptozotocin (Item No. 13104). Cayman's SIRPα Extracellular Domain (human, recombinant) protein can be used for ELISA. This protein consists of 351 amino acids, has a calculated molecular weight of 39 kDa, and a predicted N-terminus of Glu31 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of this protein is 45 to 50 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥98% estimated by SDS-PAGE
上一个:TIGIT Extracellular Domain (human, recombinant)
下一个:LAG-3 Extracellular Domain (human, recombinant)
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