NOD1(又称CARD4)和NOD2(又称CARD15)是能感知细菌肽聚糖(PGN)成份的细胞内模式识别受体。NOD1识别全部革兰氏阴性菌和部分革兰氏阳性菌PGN成份中的iE-DAP，而NOD2则识别差不多全部细菌都带有的MDP结构。iE-DAP和MDP成份必须通过细菌侵入细胞或其它细胞物质摄入方式进入到细胞后才能被识别。识别配体后，NOD1和NOD2形成多聚体，通过RIP2激酶的丝氨酸/酪氨酸来传递讯号。激活后的RIP2可泛素化修饰NEMO/IKK©，从而引起NF-kB的活化和炎症因子的释放。
NOD1/2激动剂相关产品：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
NOD1 Agonists |
C12-iE-DAP | Acylated derivative of iE-DAP | TLR2 -/ TLR4 - | 1 ng - 1 µg/ml | 1 mg | tlrl-c12dap |
C14-Tri-LAN-Gly NEW | Meso‑lanthionine tri-peptide (CL243) | TLR2 -/ TLR4 - | 1 ng - 1 µg/ml | 1 mg | tlrl-ctlg |
iE-DAP | D-γ-Glu-mDAP | TLR2 -/ TLR4 - | 1 - 100 µg/ml | 5 mg | tlrl-dap |
iE-Lys | iE-DAP negative control | TLR2 -/ TLR4 - | 1 - 100 µg/ml | 5 mg | tlrl-lys |
Tri-DAP | L-Ala-γ-D-Glu-mDAP | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 1 mg | tlrl-tdap |
NOD2 Agonists |
CL429 | Pam2C-conjugated murabutide | TLR2 +/ TLR4 - | 1 ng - 10 µg/ml | 5 mg | tlrl-c429 |
CL429 VacciGrade™ | TLR2/NOD2 agonist | VacciGrade™ | 20 -50 µg/mouse | 5 mg | vac-c429 |
L18-MDP | Muramyldipeptide with a C18 fatty acid chain | TLR2 -/ TLR4 - | 1 - 100 ng/ml | 1 mg | tlrl-lmdp |
MDP | Muramyldipeptide (L-D isoform, active) | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 5 mg | tlrl-mdp |
MDP control | Muramyldipeptide (D-D isoform, inactive) | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 5 mg | tlrl-mdpc |
M-TriLYS | Synthetic muramyl tripeptide | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 1 mg | tlrl-mtl |
Murabutide | Synthetic derivative of muramyldipeptide | TLR2 -/ TLR4 - | 1 - 100 ng/ml | 5 mg | tlrl-mbt |
N-Glycolyl-MDP | N-glycolylated muramyldipeptide | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 5 mg | tlrl-gmdp |
NOD1/2 Agonists |
M-TriDAP | MurNAc-L-Ala-γ-D-Glu-mDAP | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 1 mg | tlrl-mtd |
PGN-ECndi Ultrapure | Insoluble peptidoglycan from E. coli K12 | TLR2 -/ TLR4 - | 1 - 5 µg/ml | 5 mg | tlrl-kipgn |
PGN-ECndss Ultrapure | Soluble sonicated peptidoglycan from E. coli K12 | TLR2 -/ TLR4 - | 1 - 5 µg/ml | 1 mg | tlrl-ksspgn |
PGN-SAndi Ultrapure | Insoluble peptidoglycan from S. aureus | TLR2 -/ TLR4 - | 1 - 5 µg/ml | 5 mg | tlrl-sipgn |
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