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Recombinant Human SDF-1gamma (CXCL12)
品牌：PeproTech
货号：300-28G-100ug 规格：100ug 目录价：￥12819
货号：300-28G-10ug 规格：10ug 目录价：￥2850
货号：300-28G-1mg 规格：1mg 目录价：￥51397
货号：300-28G-250ug 规格：250ug 目录价：￥22431
货号：300-28G-2ug 规格：2ug 目录价：￥1169
货号：300-28G-500ug 规格：500ug 目录价：￥33338
产品详情
产品名称:
Recombinant Human SDF-1gamma (CXCL12)
别名:
Stromal‐Cell Derived Factor‐1, PBSF
产品描述:
The SDF‐1 proteins are stromal‐derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF‐1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF‐1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF‐1 have been found with SDF‐1alpha being the predominant form, expressing in a wide range of cell types. The SDF‐1gamma isoform is distinctive in that it contains a highly basic C‐terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS). Consequently, most of SDF‐1gamma exists in a cell‐ and membrane‐bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF‐1gamma binds with reduced affinity to the CXCR4 receptor when compared to the alpha and beta isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF‐1 isoforms. SDF‐1gamma expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat). Recombinant Human SDF‐1gamma (CXCL12) is an 11.6 kDa protein containing 98 amino acid residues.
宿主来源:
E.coli
预期分子量:
11.6 kDa
产品形式:
Standard
产地:
美国
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