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折扣/货期| 货号：35728-1 mg | 规格：1 mg | 目录价：￥38358 |
| 货号：35728 | 规格：100 µg | 目录价：￥5904 |
产品详情
产品名称:
P-Selectin/CD62P (mouse, recombinant)
别名:
CD62 Antigen-like Family Member P|GMP140|Granule Membrane Protein 140|PADGEM|Platelet Activation-dependent Granule-external Membrane Protein|Platelet-selectin|SELP
产品描述:
P-selectin, also known as CD62P, is a glycoprotein and cell adhesion molecule that is encoded by Selp in mice.{60879} It is a homodimer and is composed of an N-terminal calcium-dependent lectin domain that recognizes glycoproteins, an EGF-like domain, nine consensus repeats, a transmembrane domain, and an intracellular C-terminal tail. P-selectin is expressed in platelets, endothelial cells, and macrophages, is stored in α-granules of platelets, and localizes to the plasma membrane upon platelet activation.{60888,60889,60879} It also exists as a soluble form that results from alternative splicing of SELP.{60879} P-selectin is involved in tethering and rolling of leukocytes during inflammation and tissue healing mediated by binding to P-selectin glycoprotein ligand-1 (PSGL-1), a mucin expressed on the surface of leukocytes.{60879,60890} Selp knockout delays fatty streak formation and progression to the fibrous plaque stage in LDL receptor-deficient mice fed an atherogenic diet.{60942} It also delays aortic lesion progression in ApoE-/- mice.{60943} Cayman's P-Selectin/CD62P (mouse, recombinant) protein can be used for cell-based assays. This protein consists of 679 amino acids, has a calculated molecular weight of 74 kDa, and a predicted N-terminus of Trp42 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 116 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
上一个:E-Selectin/CD62E Extracellular Domain (human, recombinant)
下一个:Scavenger Receptor B2/CD36 Extracellular Domain (mouse, recombinant)
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