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P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, recombinant; His-tagged)
品牌:Cayman
货号:38072-1 mg 规格:1 mg 目录价:¥26820
货号:38072 规格:100 µg 目录价:¥5364
产品详情
产品名称:
P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, recombinant; His-tagged)
别名:
CD162|Cluster Of Differentiation 162|PSGL-1|Selectin P Ligand|SELPLG
产品描述:
P-selectin glycoprotein ligand 1 (PSGL-1), also known as CD162, is a cell surface glycoprotein encoded by SELPLG in humans that binds to P-, E-, and L-selectins to mediate the rolling and tethering of immune cells on endothelium for migration into sites of inflammation.{67272,67274,67276} It is expressed as a homodimer on myeloid and lymphoid cells, including platelets, and is composed of an extracellular domain, which contains branching sites for glycosylation and sulfation, a transmembrane domain, and a cytoplasmic domain.{67274} PSGL-1 selectin binding requires post-translational modifications, including sulfation and glycosylation, and these modifications are constitutively present on PSGL-1 in innate immune cells and differentiated T cells.{67275} Ectopic expression of PSGL-1 in CD4+ T cells inhibits processing and incorporation of the HIV-1 envelope glycoprotein, disrupting attachment of viral progeny to target cells but does not inhibit HIV-1 infection.{67273} It also inhibits the incorporation of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 spike glycoproteins into pseudovirions and blocks pseudovirus attachment and infection of target cells.{67276} Cayman’s PSGL-1 (human, recombinant; His-tagged) protein consists of 289 amino acids, has a calculated molecular weight of 30.5 kDa, and a predicted N-terminus of Leu18 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 89 or 61 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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