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IL-33 (oxidation resistant) (human) (rec.) (untagged)
品牌： Adipogen
产品货号： AG-40B-0160-C100
规格： 100 ug

报价：
折后价：

数量： - +
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    IL-33 (oxidation resistant) (human) (rec.) (untagged)
  • 别名:
    IL-33 (human) (C208S/C232S Mutant); Interleukin-33 (human) (C208S/C232S Mutant); IL-1F11; NF-HEV
  • 产品描述:
    Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 免疫原:
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  • 产品浓度:
    After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~17kDa (SDS-PAGE); Monomer (Size Exclusion Chromatography)
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Contains PBS + 1mM DTT
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
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  • 样本类型:
    Lyophilized. Contains PBS + 1mM DTT
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
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