| 编号 | 产品名称 | 功能 | 纯度 |
| 14489 | ASH1L bromodomain (humanre
combinant) | ASH1L is a histone methyltransferase that
regulates mammalian Hox gene expression,
which plays an important role in haemato-
poietic development in mammals. | ≥90% |
| 14490 | ATAD2 bromodomain (human
recombinant) | ATAD2 is an AAA+ ATPase-containing nuclear
transcriptional coactivator for estrogen and
androgen receptors. Its bromodomain
associates with acetylated lysine 14 on histone
H3 to regulate the genes required for cell cycle
progression. | ≥90% |
| 11917 | BAZ2B bromodomain (human
recombinant) | A rare allele of BAZ2B has been identified to be
a predictor of Sudden Cardiac Death. | ≥80% |
| 11918 | BPTF bromodomain (human
recombinant) | BPTF is the largest component of the NURF
chromation remodeling complex.Its
bromodomain recognizes acetylation of lysines
in histone 4. | ≥80% |
| 11507 | BRD1 bromodomain (human
recombinant) | BRD1 has been identified as a susceptibility
gene in neurological disorders, such as
schizophrenia and bipolar affective disorder. | ≥95% |
| 11071 | BRD2 bromodomain1 (human
recombinant; GST-tagged) | A member of the BET protein family, which
plays a key role in many processes. The
bromodomains of BRD2 bind acetylated
histone tails, coupling histone acetylation
marks to the transcriptional regulation of target
promoters. | ≥95% |
| 11070 | BRD2 bromodomain 2 (human
recombinant;GST-tagged) | See Item No. 11071 for details. | ≥95% |
| 11069 | BRD2 bromodomains 1 and 2 (human
recombinant;GST-tagged) | See Item No. 11071 for details. | ≥90% |
| 11285 | BRD3 bromodomain 1 (human
recombinant) | The BET proteins play a key role in many
cellular processes, including inflammatory
gene expression, mitosis, and viral/host
interactions.The bromodomains of BRD3 bind
acetylated histone tails, coupling histone
acetylation marks to the transcriptional
regulation of target promoters. | ≥95% |
| 14658 | BRD3 bromodomain 2 (human
recombinant) | See Item No. 11285 for details. | ≥95% |
| 14864 | BRD3 bromodomain 1 and 2 (human
recombinant) | See Item No. 11285 for details. | ≥95% |
| 11068 | BRD4 bromodomain 1 (human
recombinant; GST-tagged) | The BET proteins play a key role in many
cellular processes, including inflammatory
gene expression, mitosis, and viral/host
interactions.The bromodomains of BRD4 bind
acetylated histone tails, serving to couple
histone acetylation marks to the transcriptional
regulation of target promoters. | ≥60% |
| 11720 | BRD4 bromodomain 1 (human
recombinant; His-tagged) | See Item No. 11068 for details. | ≥95% |
| 11066 | BRD4 bromodomain 2 (human
recombinant; GST-tagged) | See Item No. 11068 for details. | ≥95% |
| 11721 | BRD4 bromodomain 2 (human
recombinant; His-tagged) | See Item No. 11068 for details. | ≥95% |
| 14822 | BRD4 bromodomains 1 and 2 (human
recombinant; aa2-477) | See Item No. 11068 for details. | ≥70% |
| 11052 | BRD4 bromodomains 1 and 2 (human
recombinant; aa49-460) | See Item No. 11068 for details. | ≥90% |
| 14491 | BRD7 bromodomain (human
recombinant) | BRD7 is subunit of the polybromo-associated
BRG1-associated factor(PBAF)-specific
component of the switch/sucrose nonfermen-
table chromation-remodeling complex.It has a
tumor suppressor role by acting as a cofactor
for p53 and regulating breast cancer tumori-
genicity. | ≥90% |
| 11509 | BRD9 bromodomain (human
recombinant) | Human BRD9 contains a single bromodomain
and has five isoforms that are produced by
alternative splicing. | ≥95% |
| 11548 | BRDT bromodomain 1 (human
recombinant) | BRDT shares homology with RING3 protein.
The two bromodomains of BRDT recognize
acetylated histone H4, Loss of BRDT leads to
defects in spermatogenesis. | ≥95% |
| 11649 | BRDT bromodomain 2 (human
recombinant) | See Item No. 11548 for details. | ≥95% |
| 14492 | BRDT bromodomains 1 and 2 (human
recombinant) | See Item No. 11548 for details. | ≥95% |
| 11284 | BRG1 bromodomain (human
recombinant) | BRG1 is a member of the SWI/SNF proteins
family, which forms part of the large ATP-
dependent chromatin remodeling complex that
is requires for transciptional activation of genes
normally repressed by chromatin. | ≥95% |
| 11289 | BRM bromodomain (human
recombinant) | BRM is a member of the SWI/SNF proteins
family, which forms part of the large ATP-
dependent chromatin remodeling complex that
is requires for transciptional activation of genes
normally repressed by chromatin. | ≥95% |
| 11650 | BRPF3 bromodomain 1 (human
recombinant) | BRPF3 is a component of the MOZ/MORF
histone acetytransferase(HAT) complex.The
addition of BRPF proteins to MOZ/MORF
increases its HAT activity.This product contains
the first bromodomain of BRPF3. | ≥95% |
| 14133 | CECR2 bromodomain (human
recombinant) | CECR2 is a transcription factor that forms a
heterodimeric complex with the ATP-dependent
chromation remodeler SNF2L forming the
CERF， which plays a critical role in neurula-
tion. The bromodomain of CECR2 has strong
γ-H2AX inhibition activity suggesting that CEC-
R2 may play a role in DNA damage response. | ≥95% |
| 11288 | CREB-binding protein bromodomain (human
recombinant) | The CREBBP bromodomain has been shown
to modulate the stability and function of the
tumor suppressor protein p53. CREBBP brom-
odomain recognizes the acetylated lysine
residue 382 on p53. | ≥95% |
| 11920 | PCAF bromodomain (human recombinant) | p300/CBP-associated factor(PCAF) is a tran-
scriptional coactivator that works both as a
histone lysine acetytransferase, through its
HAT domain, and as an acety-lysine reader
throung its conserved bromodomain located
directly C-terminal to the HAT domain.The
PCAF bromodomain binds acetylated histone
H3 and H4 as well as non-histone targets. | ≥95% |
| 11652 | Polybromo-1D bromodomain 1 (human
recombinant) | PBRM1 contains six bromodomains and is a
component of the SWI/SNF complex, PBAF.
PBAF is target to acetylated sites in chromatin
by the PBRM1 bromodomains, where it plays a
role in cell cycle regulation and tumor
suppression. | ≥95% |
| 14659 | SP140 PHD and bromodomain (human
recombinant) | The C-terminal PHD and bromodomain
regions of SP140 work in concert to bind to
chromatin and regulate gene transcription.
Nuclear bodies, which are involved in the
pathogenesis of acute promyelocytic leukemia
and viral infection, consist of several
components,such as Sp100, NDP52,PML, and
SP140. | ≥95% |
| 11922 | TAF1 bromodomain 1 (human recombinant) | TAF1 is a component of transcription factor IID,
and binds to core promoter sequences at the
transcription start site. TAF1 helps control
transcription by both its kinase and histone
acetyltranferase enzymatic activities. This
protein product contains the first bromodomain
of TAF1. | ≥95% |
| 14495 | TAF1 bromodomain 2 (human recombinant) | Contains the second bromodomain of TAF1 | ≥95% |
| 14494 | TAF1 bromodomains 1 and 2 (human
recombinant) | Contains the first and second bromodomains
of TAF1 | ≥90% |
| 11653 | TRIM24 bromodomain (human recombinant) | TRIM24 is a transcriptional confactor whose
inactivation leads to hepatocellular carcinoma
in mice. The N-terminal TRIM domain of TRIM-
24 binds ligand-bound nuclear receptors, while
its tandem C-terminal plant homeo-domain
and bromodomain target TRIM24 to acetylated
histones in chromatin. | ≥95% |
| 14660 | TRIM28 PHD and bromodomain (human
recombinant) | TRIM28, a KRAB associated protein, in-
teracts with SETD1 and other methyltrans-
ferases for gene silencing of endogenous
retroviruses during embryogenesis.The PHD
finger of TRIM28 plays an important role in
gene silencing.The PHD domain and bromo-
domain of TRIM28 work together to facilitate
lysine SUMOylation, which is a requirement
for TRIM28 activity in gene silencing. | ≥85% |
| 14661 | TRIM33 PHD and bromodomain (human
recombinant) | TRIM33 is a multi-domain regulator of
transcription that is necessary for emb-
ryogenesis. TRIM33 is targeted to DNA by
its tandem PHD and bromodomain, which
bind histone 3 at H3K9me3 and
H3K18ac,respectively. | ≥80% |
| 11549 | WDR9 bromodomain 2 (human recombinant) | WDR9 pessesses two bromodomain
motifs and eight WD repeats.It is also
known to interact with BRG1 (SMARCA4). | ≥85% |