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ISG15 (human) (rec.) (Rhodamine 110)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-PS0002-C050

规格：50 ug

目录价：￥4914

产品详情

产品名称:

ISG15 (human) (rec.) (Rhodamine 110)

别名:

ISG15 Ubiquitin-like Modifier; G1P2; IFI15; IP17; UCRP

产品描述:

ISG15 (Interferon Stimulated Gene, 15kDa) is a ubiquitin-like modifier which initiates innate immune response by activating RIG-I signaling, stimulating NK-cell proliferation, inhibiting viral budding and acting as an IFNgamma-inducing cytokine. ISG15 contains two tandem ubiquitin homology domains and is cross-reactive with alpha-Ubiquitin antibodies. Conjugation of ISG15 to a substrate protein occurs through a ubiquitin like cascade via an E1 (UBE1L), E2 (UbcH8/UBE2L6) and E3 (not yet discovered.) Deconjugation normally occurs via UBP43 (USP18), however there are several viral proteases that are able to hydrolyze ISG15 conjugates in order to evade immune response. These include the OTU-containing protease of Crimean-Congo Hemorrhagic Fever nairovirus and the Papain-Like Protease (PLPro) of the SARS coronavirus.

宿主来源:

E. coli

偶联:

Rhodamine

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

~18kDa