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折扣/货期| 货号：CHI-MF-12021R-C025 | 规格：25 ug | 目录价：￥2520 |
产品详情
产品名称:
IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)
别名:
Interleukin-21 Receptor; CD360; NILR
产品描述:
Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
宿主来源:
CHO cells
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~50-100kDa
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Shows the biological function of the IL-21R moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
内毒素水平:
<1EU/mg protein (LAL test; Lonza).
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