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折扣/货期| 货号：39630-100 µg | 规格：100 µg | 目录价：￥10262 |
| 货号：39630 | 规格：50 µg | 目录价：￥5698 |
产品详情
产品名称:
GPX2 (human, recombinant)
别名:
Glutathione Peroxidase 2 (Gastrointestinal)|GSHPX2|GSHPX-GI
产品描述:
Glutathione peroxidase 2 (GPX2) is a selenocysteine-containing glutathione peroxidase that protects cells from oxidative damage.{48903} It is a homotetramer and has an active site containing selenocysteine, glutamine, asparagine, and tryptophan.{48904,67469} mRNA encoding GPX2 has been found predominantly in the liver and gastrointestinal tract and is localized to the nucleus and cytosol, and GPX2 can reduce organic peroxides, such as hydrogen-, tert-butyl-, or cumene hydroperoxide.{67465,67466,67469} It catalyzes the reduction of these reactive oxygen species (ROS) to water or their corresponding non-toxic lipid alcohols by converting glutathione (GSH) to oxidized glutathione (GSSH), reducing intracellular oxidative stress.{67466} GPX2 knockout increases inflammation and tumor growth in a dextran sulfate sodium (DSS) mouse model of inflammation-associated colon carcinogenesis.{67470} Its levels are increased in undifferentiated basal cells, but absent in lineage-restricted luminal progenitors and luminal cells, in normal human breast tissue.{67467} GPX2 levels are decreased in triple-negative- and HER2+ breast cancers, but not in luminal breast cancers, and are negatively correlated with patient survival.{67468} Cayman's GPX2 (human, recombinant) protein can be used for enzyme activity assays.
保存温度:
-20
运输温度:
-20
产品形式:
25 mM Tris-HCl, pH 8.0, with 250 mM sodium chloride, 2 mM 2-mercaptoethanol, and 10% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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