产品规格

1/5/25/50/100mg

抗体亚型

Mouse IgG2a, κ

推荐同型对照

InVivoMAb mouse IgG2a isotype control,   unknown specificity（货号：BE0085）

推荐抗体稀释液

InVivoPure™ pH7.0 Dilution   Buffer（货号：IP0070）

免疫原

Neuroblastoma cell line LAN-1

应用

in vitro induction of apoptosis in GD2+ cells

in vivo inhibition of GD2+ tumor cell growth

产品形式

PBS , pH 7.0

Contains no stabilizers or preservatives

内毒素水平

<2EU/mg (<0.002EU/μg)

使用 LAL gel clotting 测定

纯度

>95% Determined by SDS-PAGE

无菌处理

0.2 μM filtered

生产形式

从组织培养上清液中纯化得到。

纯化形式

Protein A

RRID

AB_2819045

分子量大小

150 kDa

保存条件

抗体原溶液应保存在4°C条件下，不要冷冻保存。

in vitro induction of apoptosis in GD2+ cells

Kowalczyk, A., et al. (2009). “The GD2-specific   14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of   chemotherapeutic drugs in IMR-32 human neuroblastoma cells.” Cancer Lett 281(2): 171-182.

in vivo induction of apoptosis in GD2+ cells

Mujoo, K., et al. (1989). “Functional   properties and effect on growth suppression of human neuroblastoma tumors by   isotype switch variants of monoclonal antiganglioseside GD2 antibody 14.18.” Cancer Res 49(11): 2857-2861.